Factors Affecting the Filling Accuracy of Capsule Filling Machine
Dec 06, 2022
At present, most domestic capsule filling machines are standard models for quantitative filling. The filling volume is determined by the thickness of the measuring plate and is related to the free density of the filling material. At the same time, the accuracy of the filling volume control is related to the filling structure and the influencing factors of the filling material itself.
The hygroscopicity of the filling material is a factor that affects the control accuracy of the capsule filling machine. When the filling powder or granules have high viscosity and high humidity, the worse the fluidity, the greater the viscosity will produce plugging powder. Generally, the process of mixing and filling any drug powder or granules will Humidity is controlled below 3%. In addition, the moisture absorption capacity of the filler is related to its critical relative humidity. Generally speaking, when the purity of filling powder or granules is not high, its critical relative humidity is lowered, and multi-components increase hygroscopicity. Both will make the filling process thicker, thereby increasing the volume of the charge and making powder plugging more likely to occur. Excessive water absorption can also make the medicine less effective.
Therefore, during the filling process of the capsule filling machine, the ambient humidity should be controlled at its critical relative humidity, and the corresponding relative humidity changes with the change of the drug, but the capsule body also has certain humidity requirements. Due to the low humidity of the capsule body, it is easy to break, so the humidity of the filling environment of the capsule body is generally controlled within 40-60%.
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