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How Does The Tablet Press Control The Tablet Weight

Dec 28, 2021

Increase in tablet weight difference: In the process of adding tablets, the difference in weight cannot exceed the level stipulated in the pharmacopoeia to pass, but in the process of compression, it is often found that the difference in tablet weight increases. The reasons for the treatment are as follows:

(1) Uneven punch length: It is easy to cause an increase in film weight difference, so use a caliper to check each punch before use. If the general tablet weight is light, the down-flushing activity may fail, resulting in a smaller filling amount of particles than others. You should check out the general down-flushing to remove the obstacles.
(2) The hopper or the pelletizer of the tablet press is blocked: When the pellets are compressed, if the pellets used are small, sticky or wet, and occasional foreign matter such as cotton yarn ends and tablets are mixed in the pellets, the flow is not smooth, which will cause the participation The reduction of the particles in the die hole will affect the weight of the film. If the weight of the film is suddenly reduced, the vehicle should be parked and checked.
(3) Particles cause changes in tablet weight: too wet particles, excessive fine powder, too large difference in particle thickness, and lack of smoothing agent in the particles, can also cause changes in tablet weight differences, and the quality of the particles should be improved.

(4) The reason for the change in tablet weight is that the overall situation is caused by the tablet press fault or the negligence of the task. Therefore, during the tablet press process, maintenance tasks should be done to check whether the machine is infringed, and Weigh the film once every certain time (10-20 minutes). Is the film weight in accordance with the rules?

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