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Hygroscopic Problems Of Capsule Filled Powders

Apr 11, 2022

The quality of the finished product of the capsule filling machine is not only related to the machine, but also related to the humidity of the filling material. The hygroscopicity of powder is a manifestation of the affinity between substance molecules and water molecules, which is caused by the diffusion of water molecules into the inner layer of the drug through the gas-liquid interface. The water content of the solid preparation itself is an important factor affecting its stability, because the water content is the medium in which the chemical reaction occurs. The higher the water content, the faster the reaction.

The particle size distribution of the powder is uneven, the particles are extremely large and fine, and the particle non-circularity is large, resulting in uneven bulk density of the powder loaded in the module. Solution: Re-screen the standard famaz powder to make the famaz powder particles uniform and stable, and meet the filling process requirements. Reduce the running speed of the capsule filling machine and prolong the filling process of the powder. Add flux to the powder.

The density of the particles is very small, the filling does not spread, the filling is used, and the gauge of the disk is measured, the lower the position of the filling toolbar, the lower the position, when the amount of filling is not enough, which may be higher inflation, increase. The density of the powder pile is increased by wet or granulation, allowing the load capacity of the capsule filling machine.

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