The Solution To The Problem Of Loose Tablets In The Tablet Press
Mar 21, 2022
Tableting machine medicine is a device that has certain requirements for raw materials and production processes. For some novices, some problems will be encountered more or less in the process of tableting. Here are some frequently occurring problems. Summarize and summarize.
Tablet machine loose tablet problem
After the tablet is pressed, the hardness is not enough, and the surface is numb, and it is broken when lightly pressed with fingers.
①Insufficient grinding fineness of raw and auxiliary materials, high content of fibrous or elastic materials or oil components and uneven mixing.
Solution: It can be overcome by smashing the drug through a 100-mesh sieve, selecting a more viscous binder, appropriately increasing the pressure of the tablet press, and adding an oil-based drug absorbent to mix thoroughly.
②The amount of binder or wetting agent is insufficient or improperly selected, so that the particle texture is loose or the particle thickness is unevenly distributed, and the coarse and fine particles are layered.
Solution: It can be overcome by using appropriate binder or increasing the dosage, improving the granulation process, stirring more soft materials, and mixing the particles evenly.
③The water content of the particles is too low, the over-dried particles have greater elasticity, and the materials containing crystal water lose more crystal water during the drying process of the particles, making the particles brittle and easy to loosen.
Solution: Therefore, when granulating, the water content of the granules should be controlled according to different varieties. If the granules are too dry, spray an appropriate amount of dilute ethanol (50%-60%), mix well and press into tablets.
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